First off, the CTC lasers are sighted in at 50 ft using a Master laser that was sighted off the guns sights. 50 feet is chosen due to the offset of the laser to the bore. At 50 ft it's dead on and will not be off more than the bore offset at any distance between 0 and 100 feet.
For me personally, I sight them at about 21 ft (old guy eyes). My technique is to start by aligning them to the iron sights and then aim at a specific spot on the target. If the bullet strike is off, point the laser at the same place you first aimed at and then using the supplied wrench move the laser beam to the bullet hole while holding the gun still. Shoot a couple of more rounds and use the same procedure if necessary until you are making one ragged hole

A bench rest will help but is not needed if you have good trigger control and steady aim.
One other thing to mention. I am left eye dominant and what will look sighted in using the iron sights by a right eye dominant person will almost always be to the right for me and vise versa.
For bright light conditions, you can use some 3M reflective tape on the target. When the laser hits the tape it reflects back and is then very easy to see. We use it all the time when product testing in the summer. (the only time we see the sun in Oregon :

)
Happy shooting!
Dan